The off gassing is a joke and doesnt happen. The 5500 is a pretty good mid grade window. The higher end vinyl offerings would be Okna, HiMark,
sunrise, and Soft Lite. Andersen doesnt come close in performance.

A direct competitor to Andersen Renewal is Okna Starmark which is a cellular pvc and has MUCH better energy performance numbers than Andersen. Its a heck of a window,

I'd say they both off-gas but would not enough to be concerned about, probably get a different answer every time you ask.
I do like the 100series casement window but do not care for the sill design or tilt feature of the single hung.
the price on the 5500 seems a little high, but maybe not knowing the sizes or options.
There are other vinyl windows with a narrow profile that are of good quality that should fit that price range,

Thank you for the responses. From my research I understand the 5500 would be more in my price range than the higher offerings by okna, himark, sunrise and softlite, Yet it seems to be a reputable company and solid window. Here's the price breakdown, without installation:

Simonton DH 5500, standard

1 unit 28x46 $300
1 unit 28x40 $285
5 units 28x53 $300 each
1 unit 28x53 tempered glass $300
2 units 34x50 $320 each

I'm in the Cleveland Ohio area. Do these prices seem competitive/fair?

Also,
toddinmn,
what other good quality vinyl replacement units would you recommend that have a more narrow profile than the 5500?

thank you again for your time and responses!

The off gassing argument is bunk.

There are more toxic pollutants in your home from a couple of cabinets than there are from some uPVC windows.

Andersen will have just as much, if not more, coming of of it than will the Simonton.

Where is the home located?

The Sunrise is a very narrow profile as is the Soft-Lite Imperial Pro and Bainbridge.

I would check into those other brands before you rule them out.

Check brand's WOW mentioned. I think the pricing is on the high side for the Simonton's.
The OP is in Cleveland.