Return to the Menopause Forum
| Post a Follow-Up
Saliva testing
| | |
Posted by
Leigh_K (
My Page) on
Tue, Jan 29, 02 at 7:38
| Another disappointment for the Lee crowd. Seems saliva testing for progesterone like everything else about the miracle cure won't hold up when tested in a real laboratory.
>Maturitas 2002 Jan 30;41(1):1-6
>
>Caution on the use of saliva measurements to monitor absorption of
>progesterone
>from transdermal creams in postmenopausal women.
>
>Lewis JG, McGill H, Patton VM, Elder PA.
>
>Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories,
>P.O.
>Box 151, Christchurch, New Zealand
>
>Objectives: To determine the levels of progesterone in plasma, red cells and
>saliva as well as pregnanediol-3-glucuronide excretion in postmenopausal women
>using transdermal progesterone creams. Methods: A double-blind placebo
>controlled study was carried out using 24 postmenopausal women. Creams
>(placebo,
>20 or 40 mg progesterone/g) were applied twice daily for 3 weeks followed by 1
>week without before a further 3-week treatment. Morning samples were collected
>at 0, 1, 3, 4, 7 and 8 weeks for analysis. Results: There were small increases
>in plasma progesterone levels and pregnanediol-3-glucuronide excretion
>compared
>to the placebo group and red cell progesterone levels never exceeded plasma
>levels during progesterone cream use. Saliva progesterone levels were very
>high
>and variable in the progesterone cream groups compared to the placebo
>group and
>presented a paradox to the usual relationship observed between plasma and
>saliva
>progesterone in premenopausal women. Conclusion: The absorption of
>progesterone
>from transdermal creams is low and we caution against the use of saliva
>measurements to monitor progesterone absorption. The low systemic
>absorption of
>progesterone may not be due to peripheral conversion by
>5alpha-reductase(s). We
>also conclude that the low level of progesterone associated with red cells
>suggests they are not important in the delivery of progesterone to target
>tissues.
>
>PMID: 11809337 [PubMed - in process] |
Follow-Up Postings:
RE: Saliva testing
| | |
| Leigh, can you give me the URL of the natural menopause website---I think it was you that mentioned that site. Thanks |
RE: Saliva testing
| | |
| I'm sorry, I don't know what site you mean. Can you be a little more specific? |
RE: Saliva testing
| | |
| I thought that you mentioned a site one time that shows about menopause without hormones......I could have the wrong person though. |
RE: Saliva testing
| | |
| Perhaps you mean tishy's site? That's at: http://www.oxford.net/~tishy/beyond.html or you can just click below. This site is far more than just a site about dealing with menopause without hormones. It has a wealth of information and links to other places with more information. It is also totally non-commercial since it accepts no advertising and sells nothing. I hope you find it useful |
Here is a link that might be useful: http://www.oxford.net/~tishy/beyond.html
RE: Saliva testing
| | |
| Thanks---this is the one!!! |
Post a Follow-Up
Please Note: Only registered members are able to post messages to this forum. If you are a member, please log in.
If you aren't yet a member, join now!
Return to the Menopause Forum
Instructions
- You must be a registered member and logged in to post messages on our forums.
- Posting is a two-step process. Once you have composed your message, you will be taken to the preview page. You will then have a chance to review the contents and make changes.
- After posting your message, you may need to refresh the forum page in order to see it.
- It is illegal to post copyrighted material without the owner's consent.
- HTML codes are allowed in the message field only.
- No advertising is allowed in any of the forums.
- If you would like to practice posting or uploading photos, please visit our Test forum.
- If you need assistance, please Contact Us and we will be happy to help.
