Return to the Menopause Forum | Post a Follow-Up

Saliva testing

Posted by Leigh_K (My Page) on
Tue, Jan 29, 02 at 7:38

Another disappointment for the Lee crowd. Seems saliva testing for progesterone like everything else about the miracle cure won't hold up when tested in a real laboratory.

>Maturitas 2002 Jan 30;41(1):1-6
> >Caution on the use of saliva measurements to monitor absorption of
>from transdermal creams in postmenopausal women.
> >Lewis JG, McGill H, Patton VM, Elder PA.
> >Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories,
>Box 151, Christchurch, New Zealand
> >Objectives: To determine the levels of progesterone in plasma, red cells and
>saliva as well as pregnanediol-3-glucuronide excretion in postmenopausal women
>using transdermal progesterone creams. Methods: A double-blind placebo
>controlled study was carried out using 24 postmenopausal women. Creams
>20 or 40 mg progesterone/g) were applied twice daily for 3 weeks followed by 1
>week without before a further 3-week treatment. Morning samples were collected
>at 0, 1, 3, 4, 7 and 8 weeks for analysis. Results: There were small increases
>in plasma progesterone levels and pregnanediol-3-glucuronide excretion
>to the placebo group and red cell progesterone levels never exceeded plasma
>levels during progesterone cream use. Saliva progesterone levels were very
>and variable in the progesterone cream groups compared to the placebo
>group and
>presented a paradox to the usual relationship observed between plasma and
>progesterone in premenopausal women. Conclusion: The absorption of
>from transdermal creams is low and we caution against the use of saliva
>measurements to monitor progesterone absorption. The low systemic
>absorption of
>progesterone may not be due to peripheral conversion by
>5alpha-reductase(s). We
>also conclude that the low level of progesterone associated with red cells
>suggests they are not important in the delivery of progesterone to target
> >PMID: 11809337 [PubMed - in process]

Follow-Up Postings:

RE: Saliva testing


can you give me the URL of the natural menopause website---I think it was you that mentioned that site.


RE: Saliva testing

I'm sorry, I don't know what site you mean. Can you be a little more specific?

RE: Saliva testing

I thought that you mentioned a site one time that shows about menopause without hormones......I could have the wrong person though.

RE: Saliva testing

Perhaps you mean tishy's site? That's at: or you can just click below. This site is far more than just a site about dealing with menopause without hormones. It has a wealth of information and links to other places with more information. It is also totally non-commercial since it accepts no advertising and sells nothing.

I hope you find it useful

Here is a link that might be useful:

RE: Saliva testing

Thanks---this is the one!!!

 o Post a Follow-Up

Please Note: Only registered members are able to post messages to this forum.

    If you are a member, please log in.

    If you aren't yet a member, join now!

Return to the Menopause Forum

Information about Posting

  • You must be logged in to post a message. Once you are logged in, a posting window will appear at the bottom of the messages. If you are not a member, please register for an account.
  • Please review our Rules of Play before posting.
  • Posting is a two-step process. Once you have composed your message, you will be taken to the preview page. You will then have a chance to review your post, make changes and upload photos.
  • After posting your message, you may need to refresh the forum page in order to see it.
  • Before posting copyrighted material, please read about Copyright and Fair Use.
  • We have a strict no-advertising policy!
  • If you would like to practice posting or uploading photos, please visit our Test forum.
  • If you need assistance, please Contact Us and we will be happy to help.

Learn more about in-text links on this page here