I'm assuming you mean the Brother SE-350 machine. I use the SA434 super hoop on my SE-350. If you have a design larger than 4x4 that you want to use, you will have to use the larger hoop and split the design or re-hoop your fabric. I choose to split my designs and use the larger hoop rather than re-hoop the material. I use Embird to split my designs. One thing to note when splitting designs and using the SE-350: the machine automatically centers the design in the hoop no matter if you have the design at the top of the hoop or at the bottom. For instance, I had a design that was 4x6 that I split into 2 sections. The first section sewed fine. I moved the hoop to the next pegs and there was a gap between the bottom of the first section and the top of the second section. I worked for a week trying to figure out the issue. What I have to do is insert a letter into the design(anything will do) at the very bottom of the second section of the design, as close to the bottom as I can get it. Make sure it is the last thing to be sticthed, then just don't stitch it. It keeps the alignment of the section correct. I use PE-Design also, but Embird has the splitting feature which PE-Design does not. If you're just using built in lettering, I don't know how that would work with the repositionable hoop as it would probably center the letters too, leaving a gap. If you're wanting to stitch a 6 inch word, say 'embroidery' horizonally across a t-shirt wihtout having to re-hoop the material, create it in PE-Design instead of using built in lettering, the rotate the design to where it looks vertical. Then you would just hoop the t-shirt 'sideways'. Of course, this is just what I find works best for me. There are many different ways to skin a cat and others may have different procedures. If you are just using the machine, no software or cards, you're going to be stuck just re-hooping your material to get anything bigger than 4x4.