It really comes down to aesthetics. If upkeep is a major overriding factor to looks, then go with the acrylic because if you can get an acrylic, one-piece unit into the space, it will be easier to clean than the tile. There is nothing porous about it. Years ago, I put an single piece Aquaglass unit into a rental apartment, and my tenant loves it--no grout, no caulk in the wet area. But I'm wondering if you can get a one-piece unit in the configuration you describe. You mention a half wall on one side?

When I remodeled my own master bath, I installed ceramic tile with glass accents on the walls because it is prettier than acrylic and will definitely make a difference when it comes to resale in this area. As a concession to maintenance, I chose to go with an acrylic base that matches the garden tub next to the shower.

In either case, to make cleaning easier, make sure to include a hand shower among the fixtures or as the showerhead if you are only installing one.