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One more option.

I think it would be nice to put the toilet at the end of the room and maybe a tall matching vanity cabinet next to it. I don't know the minimum amount of depth a tub or shower takes, but you would have a much nicer aisle in the bathroom if the shower and tub were kept at 42 in deep, especially the tub. A pocket door would be really nice, but if you wanted a swing door, I would do the tall vanity behind the door swing.