While many have posted regarding a screeching cat I still have no idea what's wrong. I have had cats, usually old, who punctuate their days with a howl or two but this cat seems different in that what starts out as a howl becomes a gut wrenching, guttural cry of what appears to be pain; she sometimes looks as if she is trying to run away from the pain Her labs and her exam reveal nothing abnormal. She is twelve years old. She will not allow being picked up, never has. She had a litter years ago; one of the kittens had the same beyond skittish characteristics. She likes affection on her terms,, standing at arm's length, always has. I have pain drops to use once or twice in order to determine if the howls are caused by pain. Weeks later I have yet to get one drop on her gums. It has been suggested I catch her and let the vet give her one analgesic shot and then see if she howls during the following hours. If she doesn't howl then I will have to go to a teaching state of the art vet hospital for further testing that is not available in the average practice. Anyone out there with this problem? Could it be dementia? Thank you.