Can anyone tell me about Premarin Cream. Yes, I know I can go searching for it, but I know someone on here will probably tell me about it faster. LOL My Dr. said I could try it for dryness. She also said if I want to continue with any hrt I need to get it specially mixed. I have not made any decisions yet. What are your thoughts about this. The cream is 0.625 mg. If I do use this is it something that will cause my periods to start again? They are off and on, and I prefer them off. Don't want to do anything to get them going. She also said the main reason she considers hrt is for bone loss during menopause. Will taking enough calcium do just as well to combat the bone loss?