Hi Ladies! Hope you all had a happy "meno" day! :) Just wondering....how long does it take for an over the counter progesterone cream to work? Ok, I know everyone is different but approximately how long does it take? It's probably mind over matter, but I had the most stressful, aggravating, crappy day but I handled it so well & it's only been day 2 of using MenoCream (bought at Walgreens) & I only appled it once both days. I am 49 years old & haven't had a period in 7 months.