I started using OTC Natural Progesterone cream a couple of months ago and around the same time became quite ithcy on my arms and around my mid section. I attributed it to dry skin, since winter was setting in. But about 2 weeks ago, when my doctor switched me from the OTC and put me on a proper dosage (I was just using a dab before, not even a quarter teaspoon), the itching got worse. I even notice some hives. I am sure this is an allergic reaction. I took a Benedryl today during an especially bad attack and within an hour, the itchiness went away. Has anyone ever experienced this. And if so, what can you do? Since I'm using Estriol vaginal cream, I really need to take some progesterone to protect the uterus. Any ideas or suggestions?