Saliva testing

Leigh_KJanuary 29, 2002

Another disappointment for the Lee crowd. Seems saliva testing for progesterone like everything else about the miracle cure won't hold up when tested in a real laboratory.

>Maturitas 2002 Jan 30;41(1):1-6

> >Caution on the use of saliva measurements to monitor absorption of

>progesterone

>from transdermal creams in postmenopausal women.

> >Lewis JG, McGill H, Patton VM, Elder PA.

> >Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories,

>P.O.

>Box 151, Christchurch, New Zealand

> >Objectives: To determine the levels of progesterone in plasma, red cells and

>saliva as well as pregnanediol-3-glucuronide excretion in postmenopausal women

>using transdermal progesterone creams. Methods: A double-blind placebo

>controlled study was carried out using 24 postmenopausal women. Creams

>(placebo,

>20 or 40 mg progesterone/g) were applied twice daily for 3 weeks followed by 1

>week without before a further 3-week treatment. Morning samples were collected

>at 0, 1, 3, 4, 7 and 8 weeks for analysis. Results: There were small increases

>in plasma progesterone levels and pregnanediol-3-glucuronide excretion

>compared

>to the placebo group and red cell progesterone levels never exceeded plasma

>levels during progesterone cream use. Saliva progesterone levels were very

>high

>and variable in the progesterone cream groups compared to the placebo

>group and

>presented a paradox to the usual relationship observed between plasma and

>saliva

>progesterone in premenopausal women. Conclusion: The absorption of

>progesterone

>from transdermal creams is low and we caution against the use of saliva

>measurements to monitor progesterone absorption. The low systemic

>absorption of

>progesterone may not be due to peripheral conversion by

>5alpha-reductase(s). We

>also conclude that the low level of progesterone associated with red cells

>suggests they are not important in the delivery of progesterone to target

>tissues.

> >PMID: 11809337 [PubMed - in process]

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Toobusy

Leigh,

can you give me the URL of the natural menopause website---I think it was you that mentioned that site.

Thanks

    Bookmark   January 29, 2002 at 1:04PM
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Leigh_K

I'm sorry, I don't know what site you mean. Can you be a little more specific?

    Bookmark   January 29, 2002 at 1:52PM
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Toobusy

I thought that you mentioned a site one time that shows about menopause without hormones......I could have the wrong person though.

    Bookmark   January 29, 2002 at 7:51PM
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Leigh_K

Perhaps you mean tishy's site? That's at:

http://www.oxford.net/~tishy/beyond.html or you can just click below. This site is far more than just a site about dealing with menopause without hormones. It has a wealth of information and links to other places with more information. It is also totally non-commercial since it accepts no advertising and sells nothing.

I hope you find it useful

Here is a link that might be useful: http://www.oxford.net/~tishy/beyond.html

    Bookmark   January 29, 2002 at 8:39PM
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Toobusy

Thanks---this is the one!!!

    Bookmark   January 29, 2002 at 9:41PM
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