I have had raynauds for a few years. I've been tested for everything that goes with it and am mildly positive for lupus as well. None of the meds have worked for me. I saw my dr. last week and we decided to try nitro paste. Today was the first day I used it and so far so good. No attacks, even when I was out in freezing weather. I was instructed to put 1/4" of pasted on both wrists with a bandaid over it and leave on for 12 hrs. then wipe off. Has anyone else tried this?