Resale. It will happen.
You hire an architect and builder to build your dream.
You enjoy that dream, and then try to sell. Well, it's hard to sell a dream that nobody else has.
And the dream turns to a nightmare because nobody likes that dream.
So then you lose the house to forclosure, and all the buyers after can't understand what you were thinking.
We did buy a custom home with a designer from hell, loved it because it isn't boring, but since we got it, we wonder, "What were they thinking?"
If you do go custom, think about resale.